Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis

JD Sherrill, PS Gao, EM Stucke, C Blanchard… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: The genetic cause of eosinophilic esophagitis (EE) has been largely
unexplored until a recent genome-wide association study identified a disease susceptibility
locus on 5q22, a region that harbors the thymic stromal lymphopoietin (TSLP) gene.
However, it is unclear whether the observed genetic associations with EE are disease-
specific or confounded by the high rate of allergy in patients with EE. In addition, the genetic
contributions of other allergy-associated genes to EE risk have not been explored …