Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma
MK Cha, IH Kim - Cancer epidemiology, 2009 - Elsevier
Glutaredoxin (Glrx) uses the reducing power of glutathione to maintain and regulate the
cellular redox state. Substantial evidence indicates that the alteration of cellular redox status
is a critical factor involved in cell growth and death and results in tumorigenesis. We
investigated levels of expression of all Glrx genes in a variety of cancers using a real-time
polymerase chain reaction (RT-PCR). Among members of the Glrx, family, Glrx3 (PICOT:
PKC-interacting cousin of thioredoxin) was preferentially induced in lung (55.3±30.1-fold …
cellular redox state. Substantial evidence indicates that the alteration of cellular redox status
is a critical factor involved in cell growth and death and results in tumorigenesis. We
investigated levels of expression of all Glrx genes in a variety of cancers using a real-time
polymerase chain reaction (RT-PCR). Among members of the Glrx, family, Glrx3 (PICOT:
PKC-interacting cousin of thioredoxin) was preferentially induced in lung (55.3±30.1-fold …
