A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
J Gubbay, J Collignon, P Koopman, B Capel… - Nature, 1990 - nature.com
J Gubbay, J Collignon, P Koopman, B Capel, A Economou, A Münsterberg, N Vivian…
Nature, 1990•nature.comA gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a
line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal
development consistent with its having a role in testis determination. This gene is a member
of a new family of at least five mouse genes, related by an amino-acid motif showing
homology to other known or putative DNA-binding domains.
line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal
development consistent with its having a role in testis determination. This gene is a member
of a new family of at least five mouse genes, related by an amino-acid motif showing
homology to other known or putative DNA-binding domains.
Abstract
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
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