Negative selection and autoimmunity
PS Ohashi - Current opinion in immunology, 2003 - Elsevier
Current opinion in immunology, 2003•Elsevier
The impaired elimination of self-reactive T cells is one factor that contributes to
autoimmunity. Although the mechanism of thymic negative selection has been studied for
decades, recent data demonstrate that the mechanisms underlying this fundamental process
remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice
have demonstrated the importance of thymic negative selection in autoimmune disease
progression in mice and humans.
autoimmunity. Although the mechanism of thymic negative selection has been studied for
decades, recent data demonstrate that the mechanisms underlying this fundamental process
remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice
have demonstrated the importance of thymic negative selection in autoimmune disease
progression in mice and humans.
The impaired elimination of self-reactive T cells is one factor that contributes to autoimmunity. Although the mechanism of thymic negative selection has been studied for decades, recent data demonstrate that the mechanisms underlying this fundamental process remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice have demonstrated the importance of thymic negative selection in autoimmune disease progression in mice and humans.
Elsevier