Immunization of patients with metastatic melanoma using both class I-and class II-restricted peptides from melanoma-associated antigens
GQ Phan, CE Touloukian, JC Yang… - Journal of …, 2003 - journals.lww.com
Cancer vaccines targeting CD8+ T cells have been successful in eliciting immunologic
responses but disappointing in inducing clinical responses. Strong evidence supports the
importance of CD4+ T cells in “helping” cytotoxic CD8+ cells in antitumor immunity. We
report here on two consecutive clinical trials evaluating the impact of immunization with both
human leukocyte antigen class I-and class II-restricted peptides from the gp100 melanoma
antigen. In Protocol 1, 22 patients with metastatic melanoma were immunized with two …
responses but disappointing in inducing clinical responses. Strong evidence supports the
importance of CD4+ T cells in “helping” cytotoxic CD8+ cells in antitumor immunity. We
report here on two consecutive clinical trials evaluating the impact of immunization with both
human leukocyte antigen class I-and class II-restricted peptides from the gp100 melanoma
antigen. In Protocol 1, 22 patients with metastatic melanoma were immunized with two …