Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
KM Tewey, TC Rowe, L Yang, BD Halligan, LF Liu - Science, 1984 - science.org
KM Tewey, TC Rowe, L Yang, BD Halligan, LF Liu
Science, 1984•science.orgAdriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids
and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to
a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16
and VM-26), adriamycin has been shown to induce single-and double-strand breaks in
DNA. These strand breaks are unusual because a covalently bound protein appears to be
associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA …
and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to
a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16
and VM-26), adriamycin has been shown to induce single-and double-strand breaks in
DNA. These strand breaks are unusual because a covalently bound protein appears to be
associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA …
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16 and VM-26), adriamycin has been shown to induce single- and double-strand breaks in DNA. These strand breaks are unusual because a covalently bound protein appears to be associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs.
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