Regulation and functions of Blimp-1 in T and B lymphocytes
G Martins, K Calame - Annu. Rev. Immunol., 2008 - annualreviews.org
B lymphocyte–induced maturation protein-1 (Blimp-1), discovered 16 years ago as a
transcriptional repressor of the IFNβ promoter, plays fundamentally important roles in many
cell lineages and in early development. This review focuses on Blimp-1 in lymphocytes. In
the B cell lineage, Blimp-1 is required for development of immunoglobulin-secreting cells
and for maintenance of long-lived plasma cells (LLPCs). Direct targets of Blimp-1 and the
transcriptional cascades Blimp-1 initiates to trigger plasmacytic differentiation are described …
transcriptional repressor of the IFNβ promoter, plays fundamentally important roles in many
cell lineages and in early development. This review focuses on Blimp-1 in lymphocytes. In
the B cell lineage, Blimp-1 is required for development of immunoglobulin-secreting cells
and for maintenance of long-lived plasma cells (LLPCs). Direct targets of Blimp-1 and the
transcriptional cascades Blimp-1 initiates to trigger plasmacytic differentiation are described …