[HTML][HTML] Serum antibodies against Panton–Valentine leukocidin in a normal population and during Staphylococcus aureus infection
M Croze, O Dauwalder, O Dumitrescu, C Badiou… - Clinical Microbiology …, 2009 - Elsevier
M Croze, O Dauwalder, O Dumitrescu, C Badiou, Y Gillet, AL Genestier, F Vandenesch…
Clinical Microbiology and Infection, 2009•ElsevierTo determine whether Staphylococcus aureus Panton–Valentine leukocidin (PVL) is
expressed during human infection, anti-PVL antibody titres were compared in patients with
PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence
of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL
antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-
fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection …
expressed during human infection, anti-PVL antibody titres were compared in patients with
PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence
of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL
antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-
fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection …
Abstract
To determine whether Staphylococcus aureus Panton–Valentine leukocidin (PVL) is expressed during human infection, anti-PVL antibody titres were compared in patients with PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection. These results indicate that only PVL-positive S. aureus strains elicit significant anti-PVL antibody production in humans, and demonstrate the production of PVL during PVL-positive S. aureus infection. The protective role of this immune response remains to be established.
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