Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination

TM Kündig, CP Kalberer, H Hengartner… - Vaccine, 1993 - Elsevier
TM Kündig, CP Kalberer, H Hengartner, RM Zinkernagel
Vaccine, 1993Elsevier
The effects of immunity to vaccinia virus on the efficiency of vaccination with a vaccinia
recombinant virus were studied. In mice the efficiency and duration of the B-cell response to
the recombinant gene product of a second vaccinia recombinant virus were suppressed for
more than 9 months, ie practically lifelong. Antibody titres against the recombinant gene
product were not only lower but also lasted for a shorter time. Thus, immunity to vaccinia
virus may influence both the titre and duration of the antibody response induced by a second …
Abstract
The effects of immunity to vaccinia virus on the efficiency of vaccination with a vaccinia recombinant virus were studied. In mice the efficiency and duration of the B-cell response to the recombinant gene product of a second vaccinia recombinant virus were suppressed for more than 9 months, i.e. practically lifelong. Antibody titres against the recombinant gene product were not only lower but also lasted for a shorter time. Thus, immunity to vaccinia virus may influence both the titre and duration of the antibody response induced by a second distinct vaccinia recombinant vaccine.
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