Harnessing human dendritic cell subsets to design novel vaccines
J Banchereau, E Klechevsky, N Schmitt… - Annals of the New …, 2009 - Wiley Online Library
Annals of the New York Academy of Sciences, 2009•Wiley Online Library
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to
infection and tolerance to self. DC plasticity and subsets are prominent determinants of the
quality of elicited immune responses. Different DC subsets display different receptors and
surface molecules and express different sets of cytokines/chemokines, all of which lead to
distinct immunological outcomes. Recent findings on human DC subsets and their functional
specialization have provided insights for the design of novel human vaccines.
infection and tolerance to self. DC plasticity and subsets are prominent determinants of the
quality of elicited immune responses. Different DC subsets display different receptors and
surface molecules and express different sets of cytokines/chemokines, all of which lead to
distinct immunological outcomes. Recent findings on human DC subsets and their functional
specialization have provided insights for the design of novel human vaccines.
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.
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