Cellular cholesterol efflux mediated by cyclodextrins: demonstration of kinetic pools and mechanism of efflux
PG Yancey, WV Rodrigueza, EPC Kilsdonk… - Journal of Biological …, 1996 - jbc.org
The efflux of cholesterol from cells in culture to cyclodextrin acceptors has been reported to
be substantially more rapid than efflux induced by other known acceptors of cholesterol
(Kilsdonk, EPC, Yancey, P., Stoudt, G., Bangerter, FW, Johnson, WJ, Phillips, MC, and
Rothblat, GH (1995) J. Biol. Chem. 270, 17250-17256). In this study, we compared the
kinetics of cholesterol efflux from cells with 2-hydroxypropyl-β-cyclodextrins and with
discoidal high density lipoprotein (HDL) particles to probe the mechanisms governing the …
be substantially more rapid than efflux induced by other known acceptors of cholesterol
(Kilsdonk, EPC, Yancey, P., Stoudt, G., Bangerter, FW, Johnson, WJ, Phillips, MC, and
Rothblat, GH (1995) J. Biol. Chem. 270, 17250-17256). In this study, we compared the
kinetics of cholesterol efflux from cells with 2-hydroxypropyl-β-cyclodextrins and with
discoidal high density lipoprotein (HDL) particles to probe the mechanisms governing the …