[HTML][HTML] BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly
to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven
essential for commitment to osteoblastogenesis, is also expressed in response to BMP2.
However, there is a gap in our knowledge of the regulatory cascade from BMP2 signaling to
the onset of osteogenesis. Here we show that BMP2 induces DLX3, a homeodomain protein
that activates Runx2 gene transcription. Small interfering RNA knockdown studies in …
to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven
essential for commitment to osteoblastogenesis, is also expressed in response to BMP2.
However, there is a gap in our knowledge of the regulatory cascade from BMP2 signaling to
the onset of osteogenesis. Here we show that BMP2 induces DLX3, a homeodomain protein
that activates Runx2 gene transcription. Small interfering RNA knockdown studies in …