[HTML][HTML] Hox proteins functionally cooperate with the GC box-binding protein system through distinct domains
M Suzuki, N Ueno, A Kuroiwa - Journal of Biological Chemistry, 2003 - ASBMB
Hox genes encode a transcriptional factor that plays a key role in regulating position-specific
cartilage pattern formation. We found that Hoxa-13 and Hoxd-13, which are members of the
Abd-B subfamily of Hox genes and are crucial for the autopod development of the limb,
stimulate transcription from the Bmp-4 promoter. This stimulation was dependent on the GC
box within the promoter and independent of the putative Hox protein binding site. The
stimulation by HoxA-13 was remarkably enhanced by cotransfection with members of a …
cartilage pattern formation. We found that Hoxa-13 and Hoxd-13, which are members of the
Abd-B subfamily of Hox genes and are crucial for the autopod development of the limb,
stimulate transcription from the Bmp-4 promoter. This stimulation was dependent on the GC
box within the promoter and independent of the putative Hox protein binding site. The
stimulation by HoxA-13 was remarkably enhanced by cotransfection with members of a …