[HTML][HTML] DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation
RH Finnell, O Spiegelstein, B Wlodarczyk, A Triplett… - The Journal of …, 2002 - Elsevier
Periconceptional folic acid supplementation has been shown to prevent up to 70% of neural
tube and other birth defects in humans; however, the mechanism is still unknown. In this
study, we tested whether defective intracellular folate transport, as achieved by inactivation
of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver
and brain from gestational day (GD) 15 15 1 2 embryos. Complete Folbp1 inactivation is
embryolethal but can be reversed by maternal folinic acid (FA) supplementation, and thus …
tube and other birth defects in humans; however, the mechanism is still unknown. In this
study, we tested whether defective intracellular folate transport, as achieved by inactivation
of the murine folate-binding protein 1 (Folbp1), affects global DNA methylation in the liver
and brain from gestational day (GD) 15 15 1 2 embryos. Complete Folbp1 inactivation is
embryolethal but can be reversed by maternal folinic acid (FA) supplementation, and thus …