Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation
YJ Kang, UR Mbonye, CJ DeLong, M Wada… - Progress in lipid …, 2007 - Elsevier
Cyclooxygenases-1 and-2 (COX-1 and-2) catalyze the committed step in prostaglandin
formation. Each isozyme subserves different biological functions. This is, at least in part, a
consequence of differences in patterns of COX-1 and COX-2 expression. COX-1 is induced
during development, and COX-1 mRNA and COX-1 protein are very stable. These latter
properties can explain why COX-1 protein levels usually remain constant in those cells that
express this isozyme. COX-2 is usually expressed inducibly in association with cell …
formation. Each isozyme subserves different biological functions. This is, at least in part, a
consequence of differences in patterns of COX-1 and COX-2 expression. COX-1 is induced
during development, and COX-1 mRNA and COX-1 protein are very stable. These latter
properties can explain why COX-1 protein levels usually remain constant in those cells that
express this isozyme. COX-2 is usually expressed inducibly in association with cell …