CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system
S Levy, SC Todd, HT Maecker - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract CD81 (TAPA-1) is a widely expressed cell-surface protein involved in an
astonishing variety of biologic responses. It has been cloned independently several times for
different functional effects and is reported to influence adhesion, morphology, activation,
proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex
with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via
the B cell receptor by bridging Ag specific recognition and CD21-mediated complement …
astonishing variety of biologic responses. It has been cloned independently several times for
different functional effects and is reported to influence adhesion, morphology, activation,
proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex
with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via
the B cell receptor by bridging Ag specific recognition and CD21-mediated complement …