Prostaglandin-Metabolizing Enzymes During Pregnancy: Characterization of NAD+-Dependent Prostaglandin Dehydrogenase, Carbonyl Reductase, and …
RT Okita, JR Okita - Critical reviews in biochemistry and molecular …, 1996 - Taylor & Francis
RT Okita, JR Okita
Critical reviews in biochemistry and molecular biology, 1996•Taylor & FrancisProstaglandins E2 and F2α regulate a number of physiological functions in reproductive
tissues, and concentrations of these bioactive modulators increase during pregnancy.
Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an
increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing
enzymes induced during pregnancy are NAD+-dependent 15-hydroxyprostaglandin
dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450 …
tissues, and concentrations of these bioactive modulators increase during pregnancy.
Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an
increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing
enzymes induced during pregnancy are NAD+-dependent 15-hydroxyprostaglandin
dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450 …
Abstract
Prostaglandins E2 and F2α regulate a number of physiological functions in reproductive tissues, and concentrations of these bioactive modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing enzymes induced during pregnancy are NAD+ -dependent 15-hydroxyprostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450-dependent prostaglandin Ω- or 20-hydroxylase. This review discusses the biochemical properties, regulation, and possible functions of these three enzymes.
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