Prostaglandin synthases: recent developments and a novel hypothesis

RJA Helliwell, LF Adams, MD Mitchell - Prostaglandins, Leukotrienes and …, 2004 - Elsevier
Cells are continuously exposed to cues, which signal cell survival or death. Fine-tuning of
these conflicting signals is essential for tissue development and homeostasis, and defective
pathways are linked to many disease processes, especially cancer [1]. It is well established
that prostaglandins (PGs), as signalling molecules, are important regulators of cell
proliferation, differentiation and apoptosis [2–5]. PG production has been a focus of many
researchers interested in the mechanisms of parturition. Previously, investigators have …