[HTML][HTML] The role of multiubiquitination in dislocation and degradation of the α subunit of the T cell antigen receptor
H Yu, RR Kopito - Journal of Biological Chemistry, 1999 - ASBMB
Unassembled α subunits of the T cell receptor (TCRα) are degraded by proteasomes
following their dislocation from the endoplasmic reticulum membrane. We previously
demonstrated that a variant of TCRα lacking lysines (KαR) is degraded by this pathway with
kinetics indistinguishable from those of the wild type protein (Yu, H., Kaung, G., Kobayashi,
S., and Kopito, RR (1997) J. Biol. Chem. 272, 20800–20804), demonstrating that
ubiquitination on lysines is not required for TCRα degradation by the proteasome. Here, we …
following their dislocation from the endoplasmic reticulum membrane. We previously
demonstrated that a variant of TCRα lacking lysines (KαR) is degraded by this pathway with
kinetics indistinguishable from those of the wild type protein (Yu, H., Kaung, G., Kobayashi,
S., and Kopito, RR (1997) J. Biol. Chem. 272, 20800–20804), demonstrating that
ubiquitination on lysines is not required for TCRα degradation by the proteasome. Here, we …