[HTML][HTML] Fas ligand induces cell-autonomous NF-κB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-α
R Imamura, K Konaka, N Matsumoto… - Journal of Biological …, 2004 - ASBMB
Fas ligand (FasL) has been well characterized as a death factor. However, recent studies
revealed that FasL possesses inflammatory activity. Here we found that FasL induces
production of the inflammatory chemokine IL-8 without inducing apoptosis in HEK293 cells.
Reporter gene assays involving wild-type and mutated IL-8 promoters and NF-κB-and AP-1
reporter constructs indicated that an FasL-induced NF-κB and AP-1 activity are required for
maximal promoter activity. FasL induced NF-κB activation with slower kinetics than did TNF …
revealed that FasL possesses inflammatory activity. Here we found that FasL induces
production of the inflammatory chemokine IL-8 without inducing apoptosis in HEK293 cells.
Reporter gene assays involving wild-type and mutated IL-8 promoters and NF-κB-and AP-1
reporter constructs indicated that an FasL-induced NF-κB and AP-1 activity are required for
maximal promoter activity. FasL induced NF-κB activation with slower kinetics than did TNF …