[HTML][HTML] Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human …
The association between elevated plasma free fatty acid (FFA) concentrations and insulin
resistance is well known. Although the cause and effect relationship between FFAs and
insulin resistance is complex, plasma FFA is negatively correlated with the expression of
peroxisome proliferator activated receptor-γ cofactor-1 (PGC-1) and nuclear encoded
mitochondrial genes. To test whether this association is causal, we infused a triglyceride
emulsion (or saline as control) into healthy subjects to increase plasma FFA for 48 h …
resistance is well known. Although the cause and effect relationship between FFAs and
insulin resistance is complex, plasma FFA is negatively correlated with the expression of
peroxisome proliferator activated receptor-γ cofactor-1 (PGC-1) and nuclear encoded
mitochondrial genes. To test whether this association is causal, we infused a triglyceride
emulsion (or saline as control) into healthy subjects to increase plasma FFA for 48 h …