Impaired gametogenesis in mice that overexpress the RNA‐binding protein HuR
M Levadoux‐Martin, A Gouble, B Jégou… - EMBO …, 2003 - embopress.org
M Levadoux‐Martin, A Gouble, B Jégou, V Vallet‐Erdtmann, J Auriol, P Mercier, D Morello
EMBO reports, 2003•embopress.orgA series of experiments, using cell culture models or in vitro assays, has shown that the RNA‐
binding protein HuR increases the half‐life of some messenger RNAs that contain
adenylate/uridylate‐rich decay elements. However, its function in an integrated system has
not yet been investigated. Here, using a mouse model, we report that misregulation of HuR,
due to expression of an HuR transgene, prevents the production of fully functional gametes.
This work provides the first evidence for a physiological function of HuR, and highlights its …
binding protein HuR increases the half‐life of some messenger RNAs that contain
adenylate/uridylate‐rich decay elements. However, its function in an integrated system has
not yet been investigated. Here, using a mouse model, we report that misregulation of HuR,
due to expression of an HuR transgene, prevents the production of fully functional gametes.
This work provides the first evidence for a physiological function of HuR, and highlights its …
A series of experiments, using cell culture models or in vitro assays, has shown that the RNA‐binding protein HuR increases the half‐life of some messenger RNAs that contain adenylate/uridylate‐rich decay elements. However, its function in an integrated system has not yet been investigated. Here, using a mouse model, we report that misregulation of HuR, due to expression of an HuR transgene, prevents the production of fully functional gametes. This work provides the first evidence for a physiological function of HuR, and highlights its involvement in spermatogenesis.
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