Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common …
D Perregaux, CA Gabel - Journal of Biological Chemistry, 1994 - jbc.org
Lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages produce large
quantities of interleukin (IL)-1 beta but in the absence of a secondary stimulus little of this
cytokine is proteolytically processed to its mature biologically active state and externalized.
The potassium-proton ionophore nigericin and ATP are known to promote the maturation
and release of IL-1 beta from LPS-stimulated cells. We investigated the mechanisms by
which these agents act in an attempt to understand requirements of the post-translational …
quantities of interleukin (IL)-1 beta but in the absence of a secondary stimulus little of this
cytokine is proteolytically processed to its mature biologically active state and externalized.
The potassium-proton ionophore nigericin and ATP are known to promote the maturation
and release of IL-1 beta from LPS-stimulated cells. We investigated the mechanisms by
which these agents act in an attempt to understand requirements of the post-translational …