[HTML][HTML] TRIM5α selectively binds a restriction-sensitive retroviral capsid
S Sebastian, J Luban - Retrovirology, 2005 - Springer
S Sebastian, J Luban
Retrovirology, 2005•SpringerTRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA)
residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain
unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are
recognized and targeted for restriction is unknown. Here we show that TRIM5α binds
retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient
discrimination to account for the exquisite specificity of restriction.
residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain
unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are
recognized and targeted for restriction is unknown. Here we show that TRIM5α binds
retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient
discrimination to account for the exquisite specificity of restriction.
Abstract
TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.
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