Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression
In studies of gene regulation of keratin 16, we reported previously that simian virus 40
promoter factor 1 shows a functional cooperation with c-Jun and coactivators p300/CBP in
driving the transcriptional regulation of epidermal growth factor (EGF)-induced keratin 16
gene expression. In the present study, we found that the stimulated expression of keratin 16
by EGF was mediated mainly through the mitogen-activated protein kinase kinase–
extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway. Ser63 and …
promoter factor 1 shows a functional cooperation with c-Jun and coactivators p300/CBP in
driving the transcriptional regulation of epidermal growth factor (EGF)-induced keratin 16
gene expression. In the present study, we found that the stimulated expression of keratin 16
by EGF was mediated mainly through the mitogen-activated protein kinase kinase–
extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway. Ser63 and …
