The Sir2 family of protein deacetylases
G Blander, L Guarente - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract The yeast SIR protein complex has been implicated in transcription silencing and
suppression of recombination. The Sir complex represses transcription at telomeres, mating-
type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in
organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD+-
dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In
this review, we discuss the role of NAD+, the unusual products of the deacetylation reaction …
suppression of recombination. The Sir complex represses transcription at telomeres, mating-
type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in
organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD+-
dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In
this review, we discuss the role of NAD+, the unusual products of the deacetylation reaction …
