[HTML][HTML] Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
D Frescas, L Valenti, D Accili - Journal of Biological Chemistry, 2005 - ASBMB
Activation of NAD-dependent deacetylases, or Sirtuins, prolongs life span and mimics the
effects of caloric restriction in yeast. The FoxO subfamily of forkhead transcription factors has
been shown to mediate some of the effects of Sirtuins. Here we have shown that Sirtuin
activation or hydrogen peroxide treatment overrides the phosphorylation-dependent nuclear
exclusion of FoxO1 caused by growth factors and causes nuclear translocation of FoxO1 in
hepatocytes. Kinetic measurements of nuclear fluorescence recovery after photobleaching …
effects of caloric restriction in yeast. The FoxO subfamily of forkhead transcription factors has
been shown to mediate some of the effects of Sirtuins. Here we have shown that Sirtuin
activation or hydrogen peroxide treatment overrides the phosphorylation-dependent nuclear
exclusion of FoxO1 caused by growth factors and causes nuclear translocation of FoxO1 in
hepatocytes. Kinetic measurements of nuclear fluorescence recovery after photobleaching …