Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein AI and B-100 kinetics

AH Lichtenstein, JS Cohn, DL Hachey, JS Millar… - Journal of lipid …, 1990 - ASBMB
The production rates of apolipoprotein (apo) B-100 in very low density lipoprotein and in low
density lipoprotein and apolipoprotein AI in high density lipoprotein were determined using
a primed-constant infusion of [5, 5, 5,-2H3] leucine,[4, 4, 4,-2H3] valine, and [6, 6-2H2, 1, 2-
13C2] lysine. The three stable isotope-labeled amino acids were administered
simultaneously to determine whether absolute production rates calculated using a stochastic
model were independent of the tracer species utilized. Three normolipidemic adult males …