Characterization of antigen-presenting dendritic cells in the peripheral blood and colonic mucosa of patients with ulcerative colitis

Y Ikeda, F Akbar, H Matsui, M Onji - European journal of …, 2001 - journals.lww.com
Objective Increased lymphocyte activation and production of inflammatory cytokines are
implicated in the pathogenesis of ulcerative colitis. Because antigen-presenting dendritic
cells play a cardinal role in the activation and survival of activated lymphocytes, the aim of
the present study was to characterize dendritic cells in ulcerative colitis. Design This study
was designed to compare the phenotypes and functions of peripheral blood dendritic cells
among healthy normal volunteers and patients with ulcerative colitis or Crohn's disease …