Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins
AB Cantor, SH Orkin - Seminars in cell & developmental biology, 2005 - Elsevier
AB Cantor, SH Orkin
Seminars in cell & developmental biology, 2005•ElsevierThe Friend of GATA (FOG) family of proteins is an evolutionarily conserved class of large
multitype zinc finger cofactors that bind to the amino zinc finger of GATA transcription factors
and modulate their activity. Two FOG genes have been identified in mammals, both of which
interact with each of the six known vertebrate GATA factors in vitro. Physical interaction
between FOG and GATA proteins in vivo is essential for the development of a broad array of
tissues, reflecting the overlapping expression patterns of these factors. In this review, we will …
multitype zinc finger cofactors that bind to the amino zinc finger of GATA transcription factors
and modulate their activity. Two FOG genes have been identified in mammals, both of which
interact with each of the six known vertebrate GATA factors in vitro. Physical interaction
between FOG and GATA proteins in vivo is essential for the development of a broad array of
tissues, reflecting the overlapping expression patterns of these factors. In this review, we will …
The Friend of GATA (FOG) family of proteins is an evolutionarily conserved class of large multitype zinc finger cofactors that bind to the amino zinc finger of GATA transcription factors and modulate their activity. Two FOG genes have been identified in mammals, both of which interact with each of the six known vertebrate GATA factors in vitro. Physical interaction between FOG and GATA proteins in vivo is essential for the development of a broad array of tissues, reflecting the overlapping expression patterns of these factors. In this review, we will discuss the identification and characterization of FOG proteins, their role in human disease, and recent studies that shed new light on their function and regulation.
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