Macrophage foam cell formation with native low density lipoprotein
HS Kruth, W Huang, I Ishii, WY Zhang - Journal of Biological Chemistry, 2002 - jbc.org
This investigation has elucidated a mechanism for development of macrophage foam cells
when macrophages are incubated with native low density lipoprotein (LDL). LDL is believed
to be the main source of cholesterol that accumulates in monocyte-derived macrophages
within atherosclerotic plaques, but native LDL has not previously been shown to cause
substantial cholesterol accumulation when incubated with macrophages. We have found
that activation of human monocyte-derived macrophages with phorbol 12-myristate 13 …
when macrophages are incubated with native low density lipoprotein (LDL). LDL is believed
to be the main source of cholesterol that accumulates in monocyte-derived macrophages
within atherosclerotic plaques, but native LDL has not previously been shown to cause
substantial cholesterol accumulation when incubated with macrophages. We have found
that activation of human monocyte-derived macrophages with phorbol 12-myristate 13 …
