▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during
embryogenesis is the highly conserved Wnt family of secreted proteins. Recent biochemical
and genetic analyses have greatly enriched our understanding of how Wnts signal, and the
list of canonical Wnt signaling components has exploded. The data reveal that multiple
extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels …