HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
V Avettand-Fènoël, F Boufassa, J Galimand… - Journal of clinical …, 2008 - Elsevier
BACKGROUND: HIV-1 DNA levels, reported as copies/106 peripheral blood mononuclear
cells (PBMC), are very predictive of disease progression in seroconverters, independently of
CD4+ T cell count and HIV-RNA. Previously, HIV-DNA levels have sometimes been reported
by other means: copies/106 CD4+ T cells, reflecting the proportion of infected cells; or
copies/mL whole blood, reflecting the global blood reservoir size. OBJECTIVES: We
investigated if the predictive value over the natural course of the disease depends on how …
cells (PBMC), are very predictive of disease progression in seroconverters, independently of
CD4+ T cell count and HIV-RNA. Previously, HIV-DNA levels have sometimes been reported
by other means: copies/106 CD4+ T cells, reflecting the proportion of infected cells; or
copies/mL whole blood, reflecting the global blood reservoir size. OBJECTIVES: We
investigated if the predictive value over the natural course of the disease depends on how …