Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
SM Eggan, T Hashimoto, DA Lewis - Archives of general …, 2008 - jamanetwork.com
Context Cannabis use is associated with both impaired cognitive functions, including
working memory, and an increased risk of schizophrenia. Schizophrenia is characterized by
impairments in working memory that are associated with reduced γ-aminobutyric acid
(GABA) neurotransmission in the dorsolateral prefrontal cortex. The cannabinoid 1 receptor
(CB1R) is highly expressed in the dorsolateral prefrontal cortex, is contained in the axon
terminals of a subpopulation of perisomatic-targeting GABA neurons, and, when activated …
working memory, and an increased risk of schizophrenia. Schizophrenia is characterized by
impairments in working memory that are associated with reduced γ-aminobutyric acid
(GABA) neurotransmission in the dorsolateral prefrontal cortex. The cannabinoid 1 receptor
(CB1R) is highly expressed in the dorsolateral prefrontal cortex, is contained in the axon
terminals of a subpopulation of perisomatic-targeting GABA neurons, and, when activated …
