[HTML][HTML] Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain
SN Sarkar, HL Smith, TM Rowe, GC Sen - Journal of Biological Chemistry, 2003 - ASBMB
Double-stranded (ds) RNA, a common product of viral infection, can induce transcription of
many cellular genes, including the 561 gene that encodes P56, a regulator of protein
synthesis. Here, we report that induction of the 561 mRNA by exogenous dsRNA is
mediated by Toll-like receptor 3 (TLR3), and it requires no new protein synthesis. Because
gene induction by dsRNA is blocked by inhibitors of tyrosine kinases, we investigated the
potential roles of the five tyrosine residues present in the cytoplasmic domain of TLR3 by …
many cellular genes, including the 561 gene that encodes P56, a regulator of protein
synthesis. Here, we report that induction of the 561 mRNA by exogenous dsRNA is
mediated by Toll-like receptor 3 (TLR3), and it requires no new protein synthesis. Because
gene induction by dsRNA is blocked by inhibitors of tyrosine kinases, we investigated the
potential roles of the five tyrosine residues present in the cytoplasmic domain of TLR3 by …