RNA interference and chemically modified small interfering RNAs
M Manoharan - Current opinion in chemical biology, 2004 - Elsevier
Current opinion in chemical biology, 2004•Elsevier
RNA interference (RNAi) is a powerful biological process for specific silencing of gene
expression in diversified eukaryotic cells and has tremendous potential for functional
genomics, drug discovery through in vivo target validation, and development of novel gene-
specific medicine. The future success of this technology relies on identifying appropriate
chemical modifications to improve stability, potency and in vivo cellular delivery. The present
review summarizes the role of the chemist's toolbox in this emerging technology.
expression in diversified eukaryotic cells and has tremendous potential for functional
genomics, drug discovery through in vivo target validation, and development of novel gene-
specific medicine. The future success of this technology relies on identifying appropriate
chemical modifications to improve stability, potency and in vivo cellular delivery. The present
review summarizes the role of the chemist's toolbox in this emerging technology.
RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine. The future success of this technology relies on identifying appropriate chemical modifications to improve stability, potency and in vivo cellular delivery. The present review summarizes the role of the chemist's toolbox in this emerging technology.
Elsevier