Reinventing type 2 diabetes: pathogenesis, treatment, and prevention
RH Unger - Jama, 2008 - jamanetwork.com
THE CONVENTIONAL GLUCOCENTRIC PERSPECTIVE OF type 2 diabetes views
hyperglycemia as a primary disease caused by an etiologically uncertain combination of
obesity-associated insulin resistance and beta cell loss (a disease of glucose metabolism to
be treated with antihyperglycemic agents, including high-dose insulin, if necessary). By
contrast, the novel lipocentric view depicts the hyperglycemia of type 2 diabetes, and the
underlying insulin resistance and beta cell loss, as being secondary to the metabolic trauma …
hyperglycemia as a primary disease caused by an etiologically uncertain combination of
obesity-associated insulin resistance and beta cell loss (a disease of glucose metabolism to
be treated with antihyperglycemic agents, including high-dose insulin, if necessary). By
contrast, the novel lipocentric view depicts the hyperglycemia of type 2 diabetes, and the
underlying insulin resistance and beta cell loss, as being secondary to the metabolic trauma …