Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans
G Dembo, SB Park, ED Kharasch - The Journal of the American …, 2005 - pubs.asahq.org
Background Cyclooxygenase-2 (COX-2)-selective inhibitors (coxibs) are under investigation
for the potential therapy, attenuation, or prevention of neuroinflammatory and
neurodegenerative disorders. Coxibs are also a significant advance in pain therapy and are
traditionally considered to achieve analgesia via peripheral effects. However, in animals,
central nervous system (CNS) COX-2 activity and prostanoid concentrations are increased
by peripheral inflammation, central sensitization has been proposed to account for long-term …
for the potential therapy, attenuation, or prevention of neuroinflammatory and
neurodegenerative disorders. Coxibs are also a significant advance in pain therapy and are
traditionally considered to achieve analgesia via peripheral effects. However, in animals,
central nervous system (CNS) COX-2 activity and prostanoid concentrations are increased
by peripheral inflammation, central sensitization has been proposed to account for long-term …