[PDF][PDF] Negative regulation of leptin receptor signalling
D Lavens, J Piessevaux, J Tavernier - European cytokine network, 2006 - Citeseer
D Lavens, J Piessevaux, J Tavernier
European cytokine network, 2006•CiteseerLeptin was discovered as an adipostat, regulating body weight by balancing food intake and
energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial
role in a wide spectrum of other functions including immune regulation, bone formation and
fertility. Leptin signalling is under tight control. Aberrations of this stringent control system
may be implicated in a variety of pathologies. Here, we review the various mechanisms that
control cellular leptin receptor signalling.
energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial
role in a wide spectrum of other functions including immune regulation, bone formation and
fertility. Leptin signalling is under tight control. Aberrations of this stringent control system
may be implicated in a variety of pathologies. Here, we review the various mechanisms that
control cellular leptin receptor signalling.
Abstract
Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control. Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the various mechanisms that control cellular leptin receptor signalling.
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