Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers
Leptin and cholecystokinin (CCK) have a synergistic interaction in the suppression of food
intake, and afford similar gastroprotective activity. The present study was designed to
investigate the putative protective effects of CCK and leptin on acute colonic inflammation.
Leptin or CCK-8s was injected to rats intraperitoneally immediately before and 6 h after the
induction of colitis with acetic acid. CCK-A receptor antagonist (L-364,718) or CCK-B
receptor antagonist (L-365,260) was injected intraperitoneally 15 min before leptin or CCK …
intake, and afford similar gastroprotective activity. The present study was designed to
investigate the putative protective effects of CCK and leptin on acute colonic inflammation.
Leptin or CCK-8s was injected to rats intraperitoneally immediately before and 6 h after the
induction of colitis with acetic acid. CCK-A receptor antagonist (L-364,718) or CCK-B
receptor antagonist (L-365,260) was injected intraperitoneally 15 min before leptin or CCK …
