Opioid peptide–expressing leukocytes: Identification, recruitment, and simultaneously Increasing Inhibition of inflammatory pain
HL Rittner, A Brack, H Machelska… - The Journal of the …, 2001 - pubs.asahq.org
Background Inflammatory pain can be effectively controlled by an interaction of opioid
receptors on peripheral sensory nerve terminals with opioid peptides released from immune
cells upon stressful stimulation. To define the source of opioid peptide production, we sought
to identify and quantify populations of opioid-containing cells during the course of Freund's
complete adjuvant-induced hind paw inflammation in the rat. In parallel, we examined the
development of stress-induced local analgesia in the paw. Methods At 2, 6, and 96 h after …
receptors on peripheral sensory nerve terminals with opioid peptides released from immune
cells upon stressful stimulation. To define the source of opioid peptide production, we sought
to identify and quantify populations of opioid-containing cells during the course of Freund's
complete adjuvant-induced hind paw inflammation in the rat. In parallel, we examined the
development of stress-induced local analgesia in the paw. Methods At 2, 6, and 96 h after …