[HTML][HTML] Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets: cross-talk between tyrosine and serine/threonine kinases
D Crosby, AW Poole - Journal of Biological Chemistry, 2002 - ASBMB
The nonreceptor Bruton's tyrosine kinase (Btk) has been previously shown to associate
physically and functionally with members of the protein kinase C (PKC) family of
serine/threonine kinases in a variety of cell types. Here we show evidence for a novel
interaction between Btk and PKCθ in platelets activated through the adhesion receptors GP
Ib-V-IX and GP VI. Alboaggregin A, a snake venom component capable of activating both
receptors in combination, leads to tyrosine phosphorylation of Btk downstream of Src family …
physically and functionally with members of the protein kinase C (PKC) family of
serine/threonine kinases in a variety of cell types. Here we show evidence for a novel
interaction between Btk and PKCθ in platelets activated through the adhesion receptors GP
Ib-V-IX and GP VI. Alboaggregin A, a snake venom component capable of activating both
receptors in combination, leads to tyrosine phosphorylation of Btk downstream of Src family …