Platelets play critical roles in hemostasis and thrombosis through their aggregation following
activation of integrin α IIb β 3. However, the molecular mechanism of the integrin activation
inside platelets remains largely unknown. Pharmacological experiments have demonstrated
that protein kinase C (PKC) plays an important role in platelet aggregation. Because PKC
inhibitors can have multiple substrates and given that non-PKC-phorbol ester-binding
signaling molecules have been demonstrated to play important roles, the precise …