Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium
metabolism and to regulate growth and differentiation of many cell types. More recently, it
has become clear that VDR agonists possess immunoregulatory properties and, in
particular, pronounced pro-tolerogenic activities. VDR agonists can act directly on T cells,
but DCs appear to be their primary targets. The capacity of VDR agonists to modulate DC
and T cell functions is mediated by VDR expression in both cell types and by the presence of …