Immunologic therapy of multiple sclerosis
BGW Arnason, MD - Annual review of medicine, 1999 - annualreviews.org
Three interferon β preparations (Betaseron®, Avonex®, and Rebif®) have shown efficacy in
the treatment of relapsing-remitting multiple sclerosis (MS). Attack frequency is reduced by
30% and major attacks to an even greater extent. Accumulating disease burden as
measured by annual T2-weighted magnetic resonance imaging is markedly lessened, and
disease activity as measured by serial gadolinium-enhanced MRI scanning is reduced by
over 80%. A fourth preparation, Copaxone®, a basic copolymer of four amino acids, lessens …
the treatment of relapsing-remitting multiple sclerosis (MS). Attack frequency is reduced by
30% and major attacks to an even greater extent. Accumulating disease burden as
measured by annual T2-weighted magnetic resonance imaging is markedly lessened, and
disease activity as measured by serial gadolinium-enhanced MRI scanning is reduced by
over 80%. A fourth preparation, Copaxone®, a basic copolymer of four amino acids, lessens …