Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors
Bioorganic & medicinal chemistry letters, 2006•Elsevier
Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most
potent compound was K6H2 [TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1),
0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds,(NH4) 18
[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase
inhibition might contribute to the described biological effects of polyoxometalates, including
their anti-cancer activity.
potent compound was K6H2 [TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1),
0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds,(NH4) 18
[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase
inhibition might contribute to the described biological effects of polyoxometalates, including
their anti-cancer activity.
Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140μM (NTPDase1), 0.910μM (NTPDase2), and 0.563μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.
Elsevier