[PDF][PDF] GATA-3-not just for Th2 cells anymore

IC Ho, SY Pai - Cell Mol Immunol, 2007 - cmi.ustc.edu.cn
IC Ho, SY Pai
Cell Mol Immunol, 2007cmi.ustc.edu.cn
GATA-3 was first cloned as a T cell specific transcription factor in 1991 and its importance in
the transcriptional control of T helper type 2 cell (Th2) differentiation was established in the
mid to late 90's. A role for GATA-3 during thymic development has long implied by its
continuous and regulated expression through out T lineage development, but the absolute
requirement for GATA-3 during early T lymphoid commitment/survival previously precluded
definitive answers to this question. Several technical breakthroughs have fueled fruitful …
GATA-3 was first cloned as a T cell specific transcription factor in 1991 and its importance in the transcriptional control of T helper type 2 cell (Th2) differentiation was established in the mid to late 90’s. A role for GATA-3 during thymic development has long implied by its continuous and regulated expression through out T lineage development, but the absolute requirement for GATA-3 during early T lymphoid commitment/survival previously precluded definitive answers to this question. Several technical breakthroughs have fueled fruitful investigation in recent years and uncovered unexpected and critical roles for GATA-3 in CD4 thymocyte survival, invariant natural killer T cell generation and function, and also in beta selection. Not only does GATA-3 participate in nearly every stage of T cell development from common lymphoid progenitor to Th2, conditional knockout studies have indicated that the influence of GATA-3 also extends beyond the immune system. Cellular & Molecular Immunology. 2007; 4 (1): 15-29.
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