IκB kinase-2-independent and-dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic
MA Birrell, S Wong, EL Hardaker, MC Catley… - Molecular …, 2006 - Elsevier
Nuclear factor κB (NF-κB) is a transcription factor believed to be central in the expression of
numerous inflammatory genes and the pathogenesis of many respiratory diseases. We have
previously demonstrated increased NF-κB pathway activation in a steroid-sensitive animal
model of lipopolysaccharide (LPS)-driven airway inflammation. It is noteworthy that this
phenomenon was not observed in a steroid-insensitive model of elastase-induced
inflammation in the rat. The aim of this study was to gather further evidence to suggest that …
numerous inflammatory genes and the pathogenesis of many respiratory diseases. We have
previously demonstrated increased NF-κB pathway activation in a steroid-sensitive animal
model of lipopolysaccharide (LPS)-driven airway inflammation. It is noteworthy that this
phenomenon was not observed in a steroid-insensitive model of elastase-induced
inflammation in the rat. The aim of this study was to gather further evidence to suggest that …