Interleukin-6: from basic science to medicine—40 years in immunology
T Kishimoto - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract This essay summarizes my 40 years of research in immunology. As a young
physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired
me to study the structure of IgM. I began to ask how antibody responses are regulated. In the
late 1960s, the essential role of T cells in antibody production had been reported. In search
of molecules mediating T cell helper function, I discovered activities in the culture
supernatant of T cells that induced proliferation and differentiation of B cells. This led to my …
physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired
me to study the structure of IgM. I began to ask how antibody responses are regulated. In the
late 1960s, the essential role of T cells in antibody production had been reported. In search
of molecules mediating T cell helper function, I discovered activities in the culture
supernatant of T cells that induced proliferation and differentiation of B cells. This led to my …