Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor α
WNU Chen, RL Woodbury, LE Kathmann… - Journal of Biological …, 2004 - ASBMB
In contrast to the well known cytotoxic effects of tumor necrosis factor (TNF) α in many
mammary cancer cells, we have found that TNF stimulates the proliferation and motility of
human mammary epithelial cells (HMECs). Since the response of HMECs to TNF is similar
to effects mediated by epidermal growth factor receptor (EGFR) activation, we explored the
potential role of cross-talk through the EGFR signaling pathways in mediating cellular
responses to TNF. Using a microarray enzyme-linked immunoassay, we found that exposure …
mammary cancer cells, we have found that TNF stimulates the proliferation and motility of
human mammary epithelial cells (HMECs). Since the response of HMECs to TNF is similar
to effects mediated by epidermal growth factor receptor (EGFR) activation, we explored the
potential role of cross-talk through the EGFR signaling pathways in mediating cellular
responses to TNF. Using a microarray enzyme-linked immunoassay, we found that exposure …
